Discovery of novel 2, 8-diazaspiro [4.5] decanes as orally active glycoprotein IIb-IIIa antagonists

…, L Nannizzi-Alaimo, GL Park, JL Lambing…

Index: Mehrotra, Mukund M.; Heath, Julie A.; Smyth, Mark S.; Pandey, Anjali; Rose, Jack W.; Seroogy, Joseph M.; Volkots, Deborah L.; Nannizzi-Alaimo, Lisa; Park, Gary L.; Lambing, Joseph L.; Hollenbach, Stanley J.; Scarborough, Robert M. Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2037 - 2061

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Citation Number: 21

Abstract

In our efforts to develop orally active GPIIb-IIIa antagonists with improved pharmaceutical properties, we have utilized a novel 2, 8-diazaspiro [4.5] decane scaffold as a template. We describe here our investigation of a variety of templates including spiropiperidinyl-γ-lactams, spiropiperidinylimide, spiropiperidinylureas, and spiropiperidinylhydantoins. With the appropriate acidic and basic pharmacophores in place, each template yielded analogues ...