Tetrahedron letters

Synthesis of the potent potassium channel opener Ro 31-6930 via claisen rearrangement and tandem regiocontrolled cyclisation.

MR Attwood, I Churcher, RM Dunsdon

Index: Attwood, Michael R.; Churcher, Ian; Dunsdon, Rachel M.; Hurst, David N.; Jones, Philip S. Tetrahedron Letters, 1991 , vol. 32, # 6 p. 811 - 814

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Citation Number: 22

Abstract

... Ro 31-6930 VIA CLAISEN REARRANGEMENT AND TANDEM REGIOCONTROLLED CYCLISATION Michael R Attwood, Ian Churcher, Rachel M Dunsdon, David N Hurst and PhIlIp S Jones' Roche Products LImited, Welwyn Garden Cdy, Herts AL7 3AY ... Experrmental runs for 5 hours at 165oC !n 1,2-d/chlorobenzene Analysis of products by HPLC St02 25x0 46 cm column 3O%v/v ethyl acetate / hexane UV detectton 254 nM ...