Total synthesis of jadomycin A and a carbasugar analogue of jadomycin B

M Shan, EU Sharif, GA O'Doherty

Index: Shan, Mingde; Sharif, Ehesan U.; O'Doherty, George A. Angewandte Chemie - International Edition, 2010 , vol. 49, # 49 p. 9492 - 9495

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Citation Number: 49

Abstract

Jadomycins A and B are unique members of the angucycline family of natural products with the unusual 8H-benz [b] oxazolo [3, 3-f]-phenanthridine ring system (Scheme 1). Both jadomycins A and B are produced by the Gram-positive soil bacteria Streptomyces venezuelae ISP5230 under specific nutrient and environmental stress.[1] They display important bioactivities, including antitumor, antimicrobial, anti-viral, as well as, aurora-B ...