Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites: pH stability and synthesis by human and dog liver

…, VM Lakshmi, GPW Huang, TV Zenser, BB Davis

Index: Babu, Satram R.; Lakshmi, Vijaya M.; Huang, George Pen-Wen; Zenser, Terry V.; Davis, Bernard B. Biochemical Pharmacology, 1996 , vol. 51, # 12 p. 1679 - 1685

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Citation Number: 44

Abstract

Glucuronide conjugates of arylamines are thought to be important in the carcinogenic process. This study investigated the pH stability and synthesis of glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites by human and dog liver. Both dog and human liver slices incubated with 0.06 mM [3H]-4-aminobiphenyl produced the N- glucuronide of 4-aminobiphenyl as the major product. After 2 hr of incubation, the N- ...