Tetrahedron: Asymmetry

The first total synthesis of (−)-sinulariol-B and three other cembranoids

J Lan, J Li, Z Liu, Y Li, ASC Chan

Index: Lan, Jiong; Li, Jing; Liu, Zuosheng; Li, Yulin; Chan, Albert S. C. Tetrahedron Asymmetry, 1999 , vol. 10, # 10 p. 1877 - 1885

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Citation Number: 6

Abstract

Cembranoids, a 14-membered cyclic diterpene family, have become of interest to synthetic chemists and biologists because of their unusual structures and wide range of biological activities.1 and 2Sinulariol-B 1, sinulariol-D 2, sinularial-A 3 and sinularic acid-A 4 were isolated in 1987 and 1988 from the southern Japan soft coral Sinularia mayi. 3 and 4Their geometrical structures and configurations were confirmed to be 3E, 7E, 11E and 1R, respectively, but the absolute ...