Addition of Amines to the Triple Bond in α, α, α-Trichloromethylpropargyl Mesylate: Synthesis of α, α-Dichloromethylenaminones and Preparation of 2-Phenyl-4- …
YG Si, SP Guo, WJ Wang, B Jiang
Index: Si, Yu-Gui; Guo, Song-Po; Wang, Wan-Jun; Jiang, Biao Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1494 - 1496
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Citation Number: 12
Abstract
Addition of amines to the triple bond in α,α,α-trichloromethylpropargyl mesylate to give α,α-dichloromethylenaminones and its use in the preparation of 2-phenyl-4-dichloromethylquinolines in good yields are reported. ... Alkynylation of chloral and bromal with phenylacetylene gave propargyl alcohol 1a and 1b in 95% and 83% yield, respectively, in the presence of ZnCl 2 and Et 3 N according to our previously reported procedure. 10 Initially we envisioned that treatment of the ...
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