Synthesis and structure-activity relationships of 6-substituted 2', 3'-dideoxypurine nucleosides as potential anti-human immunodeficiency virus agents
…, LS Jeong, SK Ahn, B Doboszewski…
Index: Chu, Chung K.; Ullas, Giliyar V.; Jeong, Lak S.; Ahn, Soon K.; Doboszewski, Bogdan; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 6 p. 1553 - 1561
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Citation Number: 52
Abstract
In order to study the structure-activity relationships of 2', 3'-dideoxypurine nucleosides as potential anti-HIV agents, various 6-substituted purine analogues have been synthesized and examined in virus-infected and uninfected human peripheral blood mononuclear cells. M-methyl-2', 3'-dideoxyadenosine (D2MeA, 7a) was initially synthesized from adenosine via 2', 3'-0-bisxanthate 3. As extension of this reaction to other N6-substituted compounds ...
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