Stereoselective biotransformation of permethrin to estrogenic metabolites in fish

…, JM Rimoldi, J Gan, R Lavado, D Schlenk

Index: Nillos, Mae Grace; Chajkowski, Sarah; Rimoldi, John M.; Gan, Jay; Lavado, Ramon; Schlenk, Daniel Chemical Research in Toxicology, 2010 , vol. 23, # 10 p. 1568 - 1575

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Citation Number: 25

Abstract

This study investigated the stereoselective biotransformation and resulting estrogenic activity of the pyrethroid insecticide, permethrin (PM). Results of both in vivo (male Japanese medaka, vitellogenin (VTG) protein in plasma) and in vitro (primary rainbow trout hepatocyte VTG-mRNA expression) assays indicated stereoselective estrogenic activity of PM. 1 S-cis- PM was observed to have significantly higher activity (P≤ 0.05) than the 1 R-cis ...