Organic letters

Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile

SI Maffioli, E Marzorati, A Marazzi

Index: Maffioli, Sonia I.; Marzorati, Ettore; Marazzi, Alessandra Organic Letters, 2005 , vol. 7, # 23 p. 5237 - 5239

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Citation Number: 49

Abstract

According to literature, phosphorus pentoxide, 1 titanium tetrachloride, 2 thionyl chloride, 3 and trifluoroacetic anhydride 4 are some reagents used to prepare nitriles through primary amide dehydration. In addition, more recently, methods using other reagents to perform the dehydration under milder conditions, such as PyBOP, 5 EDCI, 6 and cyanuric chloride, 7 have been reported. All of these methods are characterized by a common requirement, that is, the ...