9-Benzyl-6-(dimethylamino)-9H-purines with antirhinovirus activity

…, JA Linn, MP Krochmal, JWT Selway

Index: Kelley, James L.; Linn, James A.; Krochmal, Mark P.; Selway, J. W. T. Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 2001 - 2004

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Citation Number: 28

Abstract

A series of 9-benzyl-6-(dimethylamino)-9H-purines and 9-benzyl-2-chloro-6- (dimethylamino)-9H-purines were synthesized and tested in cell culture for activity against rhinovirus type 1B. The 9-benzylpurines that were unsubstituted in the 2-position had weak activity. However, introduction of a 2-chloro substituent resulted in a substantial increase in antiviral activity. One of the most active compounds, 2-chloro-6-(dimethylamino)-9-(4- ...