A convenient synthesis of 1H-pyrrolo (3, 2-c) quinoline-6, 9-diones and 11H-indolo (3, 2-c) quinoline-1, 4-diones derivatives.

P HELISSEY, H PARROT-LOPEZ, J RENAULT…

Index: Helissey; Parrot-Lopez; Renault; Cros Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 9 p. 3547 - 3557

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Citation Number: 15

Abstract

8-Methoxy-2, 3, 4-trimethyl-1H-pyrrolo [3, 2-c] quinoline-6, 9-dione (28) and 2-methoxy-6- methyl-7, 8, 9, 10-tetrahydro-11H-indolo [3, 2-c] quinoline-1, 4-dione (31) can be obtained from 4-hydrazino-6-methoxy-2-methyl-5-quinolinamine (21). The synthetic method consists in creating the pyrrole or indole nucleus by applying Fischer's indole synthesis to the hydrazones (22 and 24) to give the amines (23 and 25, respectively). The catalytic ...