A discriminating protecting group strategy for alcohols and amines
LJ Liotta, B Ganem
Index: Liotta, Louis J.; Ganem, Bruce Israel Journal of Chemistry, 1991 , vol. 31, # 3 p. 215 - 222
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Citation Number: 4
Abstract
Abstract The protection of alcohols and amines as O-and N-benzyl derivatives has long played a central role in organic synthesis. For cases where the conventional method of benzylation under strongly basic conditions is not applicable, we now describe an alternate method using phenyldiazomethane that proceeds under near-neutral conditions with HBF 4 as a catalyst. O-Benzylation occurs at− 40 C and works well on primary, secondary, and ...
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