Inhibitors of NF-κB derived from thalidomide

EJC De-Blanco, B Pandit, Z Hu, J Shi, A Lewis…

Index: Carcache de-Blanco, Esperanza J.; Pandit, Bulbul; Hu, Zhigen; Shi, Jiandong; Lewis, Andrew; Li, Pui-Kai Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 6031 - 6035

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Citation Number: 19

Abstract

A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-κB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF- κB activation is through inhibition of its translocation from the cytoplasm to the nucleus.