Synthesis of mercapturic acid derivatives of putative toxic metabolites of bromobenzene

RP Hanzlik, PE Weller, J Desai, J Zheng…

Index: Hanzlik, Robert P.; Weller, Paul E.; Desai, Jayant; Zheng, Jiang; Hall, Larry R.; Slaughter, Donald E. Journal of Organic Chemistry, 1990 , vol. 55, # 9 p. 2736 - 2742

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Citation Number: 28

Abstract

The synthesis and characterization of nine isomerically defined S-arylmercapturic acids of interest in connection with the metabolism of the model hepatotoxin bromobenzene is described. Included are three S-(bromophenyl)-, two S-(bromohydroxyphenyl)-, and three S- (bromodihydroxypheny1) mercapturic acids of defined substitution pattern. In addition, several related compounds with two or no bromine atoms are described. These syntheses ...