Dialkylquinoneimine metabolites of chloroacetanilide herbicides induce sister chromatid exchanges in cultured human lymphocytes

AB Hill, PR Jefferies, GB Quistad, JE Casida

Index: Hill, Anna B.; Jefferies, Phillip R.; Quistad, Gary B.; Casida, John E. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 1997 , vol. 395, # 2-3 p. 159 - 171

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Citation Number: 71

Abstract

Some of the most widely-used herbicides are the chloroacetanilides exemplified by alachlor and butachlor (derived from 2, 6-diethylaniline) and metolachlor and acetochlor (synthesized from 2-ethyl-6-methylaniline). This investigation tests the hypothesis that the previously-observed oncogenicity of these herbicides is due to genotoxic intermediates such as diethylbenzoquinoneimine, a purported alachlor metabolite. Syntheses are reported ...