Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20

F Yokokawa, A Inaizumi, T Shioiri

Index: Yokokawa, Fumiaki; Inaizumi, Akiko; Shioiri, Takayuki Tetrahedron, 2005 , vol. 61, # 6 p. 1459 - 1480

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Citation Number: 39

Abstract

The first total synthesis of a cyclic depsipeptide possessing the 3-amino-6-hydroxy-2- piperidone (Ahp) unit was successfully achieved in a convergent manner by the oxidative construction of the Ahp unit at the later stage of the synthesis. This synthetic work provides data indicating that the structure of the target Ahp-depsipeptide, micropeptin T-20, should be re-examined.