6-(Alkylamino)-9-benzyl-9H-purines. A new class of anticonvulsant agents

…, MP Krochmal, JA Linn, EW McLean…

Index: Kelley, James L.; Krochmal, Mark P.; Linn, James A.; McLean, Ed W.; Soroko, Francis E. Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 606 - 612

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Citation Number: 40

Abstract

Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats. Most compounds were prepared in three steps from 5-amino-4, 6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine. Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)-or 6-(dimethylamino) ...