Synthesis and biological activity of photoactive derivatives of erythromycin

…, F Tejedor, F Polo, JPG Ballesta

Index: Arevalo, M. Angeles; Tejedor, Francisco; Polo, Florentino; Ballesta, J. P. G. Journal of Medicinal Chemistry, 1989 , vol. 32, # 9 p. 2200 - 2204

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Citation Number: 15

Abstract

Results Synthesis of N-Substituted Erythromycin Derivatives. Five derivatives, compounds 5, 7, 9, 10, and 16 (Schemes I and 11), have been prepared by linking two different photoreactive groups, namely a p-nitrophenyl ether and an aromatic azide, to erythromycylamine. The groups have been introduced by condensation with either the carboxylic acids or the aldehyde of the appropriate compound to yield an amide bond or a ...