Synthesis and characterization of nitroaromatic peptoids: fine tuning peptoid secondary structure through monomer position and functionality

…, R Luechapanichkul, HE Blackwell

Index: Fowler, Sarah A.; Luechapanichkul, Rinrada; Blackwell, Helen E. Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1440 - 1449

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Citation Number: 30

Abstract

N-Substituted glycine oligomers, or peptoids, have emerged as an important class of foldamers for the study of biomolecular interactions and for potential use as therapeutic agents. However, the design of peptoids with well-defined conformations a priori remains a formidable challenge. New approaches are required to address this problem, and the systematic study of the role of individual monomer units in the global peptoid folding ...