Synthesis of 6-substituted purin-2-ones with potential cytokinin activity

…, AB Eriksen, B Dalhus, LL Gundersen, F Rise

Index: Andresen; Eriksen; Dalhus; Gundersen; Rise Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 14 p. 1662 - 1672

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Citation Number: 17

Abstract

6-Substituted purin-2-ones have been prepared by completely regioselective addition of Grignard reagents to an N-protected purin-2-one followed by rearomatisation and deprotection. The target compounds may be regarded as analogues of the potent cytokinins trans-zeatin and benzylaminopurine (BAP), and most of the BAP analogues did induce increased weight growth in radish cotyledons. N-Protected (E)-6-styrylpurin-2-one ...