Phosphorus-containing aminocarboxylic acids with an o-xylylene fragment. III

…, VV Grigor'ev, VA Nemanova, EN Tsvetkov

Index: Ragulin, V. V.; Grigor'ev, V. V.; Nemanova, V. A.; Tsvetkov, E. N. Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 3 p. 209 - 212 Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 3 p. 50 - 52

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Abstract

(HO) 2P (O){CH2)~ CH (NH2) COOH(I) represent a new and promising class of antispasmodic compounds, which have been studied extensively in recent years [I, 3-8]. 2- Amino-5-phosphonovaleric acid (I, n= 3) and 2-amino-7-phosphonoheptanoic (I, n= 5) acids exhibit the highest antispasmodic activity [I, 5-7] and are strong selective antagonists of N- methyl-D-aspartic (NMDA) receptors, which probably also determines their antispasmodic ...