O??Trifluoromethylation of N, N??Disubstituted Hydroxylamines with Hypervalent Iodine Reagents

…, E Pietrasiak, L Sigrist, B Czarniecki…

Index: Matousek, Vaclav; Pietrasiak, Ewa; Sigrist, Lukas; Czarniecki, Barbara; Togni, Antonio European Journal of Organic Chemistry, 2014 , vol. 2014, # 15 p. 3087 - 3092

Full Text: HTML

Citation Number: 12

Abstract

Abstract A mild trifluoromethylation reaction of N, N-disubstituted hydroxylamines that is tolerant towards a variety of functional groups, including nitriles, alcohols, ketones, esters, amides, imides, and nitrogen heterocycles, is reported. The key feature of this reaction is the activation of the CF 3 reagent with either trimethylsilyl triflate or LiClO 4 and partial or full deprotonation of the substrate with tetramethylguanidine or lithium diisopropylamide. ...