OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities

B Shi, P Tang, X Hu, JO Liu, B Yu

Index: Shi, Bingfeng; Tang, Pingping; Hu, Xiaoyi; Liu, Jun O.; Yu, Biao Journal of Organic Chemistry, 2005 , vol. 70, # 25 p. 10354 - 10367

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Citation Number: 64

Abstract

OSW saponins, featuring a 16β, 17α-dihydroxycholest-22-one aglycon and an acylated β-d- xylopyranosyl-(1→ 3)-α-l-arabinopyranosyl residue attached to the 16-hydroxyl group, have recently been discovered from a group of lily plants, which show potent antitumor activities with a novel mechanism of action. This paper describes an aldol approach to the stereoselective construction of the 16α, 17α-dihydroxycholest-22-one structure from 16α- ...