Organic letters

Highly stereoselective hydrocarbation of terminal alkynes via Pt-catalyzed hydrosilylation/Pd-catalyzed cross-coupling reactions

SE Denmark, Z Wang

Index: Denmark, Scott E.; Wang, Zhigang Organic Letters, 2001 , vol. 3, # 7 p. 1073 - 1076

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Citation Number: 127

Abstract

The formal addition of an aryl-H or alkenyl-H bond across a terminal alkyne has been accomplished by the combination of platinum-catalyzed hydrosilylation followed by palladium-catalyzed cross-coupling. The use of the t-Bu3P-Pt (DVDS) catalyst in combination with tetramethyldisiloxane gave excellent regio-and stereoselectivity with a number of alkyne substrates. Subsequent, fluoride-promoted cross-coupling proceeded in ...