Synthesis and antiinflammatory activity of some 2-methylindol-3-ylacetic acids

DN Plutitskii, YI Smushkevich, NN Suvorov…

Index: Plutitskii, D. N.; Smushkevich, Yu. I.; Suvorov, N. N.; Syubaev, R. D.; Shvarts, G. Ya. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 10 p. 733 - 737 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 10 p. 1209 - 1213

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Abstract

To synthesize esters (lll-VlI) we tried to apply the known method of the synthesis of N- alkyiindoles with the use of a basic phase transfer catalyst [3], but the attempt to phenacylate chloroacetophenone hydrazone I in the first step proved unsuccessful. In the presence of base the chloroacetophenone rapidly underwent Favorskii rearrangement, forming the phenylacetic acid. Introduction of the phenacyl moiety was successfully carried out with ...