Synthesis of 5-aryl-2-oxopyrrole derivatives as synthons for highly substituted pyrroles
…, M Kostermans, G Van Baelen, M Smet, W Dehaen
Index: Metten, Bert; Kostermans, Maarten; Van Baelen, Gitte; Smet, Mario; Dehaen, Wim Tetrahedron, 2006 , vol. 62, # 25 p. 6018 - 6028
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Citation Number: 45
Abstract
A small library of 2-oxo-5-(hetero) arylpyrroles was prepared starting from 2, 3-dioxo-5- (hetero) arylpyrrolidines. The large synthetic possibilities of these 2-oxopyrroles were investigated. The 2-oxopyrroles offer a large number of possible derivatizations including reactions with electrophiles. The chloroformylation of 2-oxo-5-(hetero) arylpyrroles provides pyrrole carbaldehydes. Some pyrrole carbaldehydes were used to synthesize polycyclic ...
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