The Journal of organic chemistry

Improved Syntheses of 3 H, 5 H-Pyrrolo [3, 2-d] pyrimidines

RH Furneaux, PC Tyler

Index: Furneaux, Richard H.; Tyler, Peter C. Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8411 - 8412

Full Text: HTML

Citation Number: 63

Abstract

The synthesis of 3H, 5H-pyrrolo [3, 2-d] pyrimidines is of renewed interest because both 2- amino-3H, 5H-pyrrolo-[3, 2-d] pyrimidin-4-one (1, 9-deazaguanine) and its deamino derivative 2 (9-deazahypoxanthine) are potential synthetic precursors of the newly discovered immucillins 3 and 4, which are extremely potent inhibitors of purine nucleoside phosphorylase. 1