Facile one step synthesis of acyl azides and Nα-Fmoc/Boc/Z protected amino acid azides employing benzotriazole-1-yl-oxy-tris-(dimethyl-amino)-phosphonium …

B Vasantha, VV Sureshbabu

Index: Vasantha; Sureshbabu, Vommina V. Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 6 p. 812 - 817

Full Text: HTML

Citation Number: 6

Abstract

Abstract: A simple route for the preparation of acyl azides from the corresponding carboxylic acids employing the peptide-coupling agent BOP is described. The procedure is simple, clean and high yielding. The chemistry is also extended to the preparation of several urethane protected amino acid azides (eight examples) as well.

Related Articles:

The challenge of palladium-catalyzed aromatic azidocarbonylation: from mechanistic and catalyst deactivation studies to a highly efficient process

[Katritzky, Alan R.; Widyan, Khalid; Kirichenko, Kostyantyn Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5802 - 5804]

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues

[Honma; Hayashi; Aoyama; Hashimoto; Machida; Fukasawa; Iwama; Ikeura; Ikuta; Suzuki-Takahashi; Iwasawa; Hayama; Nishimura; Morishima Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4615 - 4627]

Photolysis and Thermolysis of Pyridyl Carbonyl Azide Monolayers on Single??Crystal Platinum

[Adkinson, Dana K.; Magri, David C.; Pitters, Jason L.; Griffiths, Keith; Norton, Peter R.; Workentin, Mark S. Photochemistry and Photobiology, 2013 , vol. 89, # 5 p. 1020 - 1028]

Photolysis and Thermolysis of Pyridyl Carbonyl Azide Monolayers on Single??Crystal Platinum

[Adkinson, Dana K.; Magri, David C.; Pitters, Jason L.; Griffiths, Keith; Norton, Peter R.; Workentin, Mark S. Photochemistry and Photobiology, 2013 , vol. 89, # 5 p. 1020 - 1028]

More Articles...