Journal of the American Chemical Society

Sterically Hindered Phenolic Buffers. Application to Determination of Rates of Amidation of Ethyl Chloroformate1

HK Hall Jr

Index: Hall Journal of the American Chemical Society, 1957 , vol. 79, p. 5439

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Citation Number: 32

Abstract

By working in sufficiently acidic solutions, the amidation reaction was They were very high (10'1. group rendered the latter inert to acylation by ethyl chloroformate in water. studies of the amidation of ethyl chloroformate. slowed to measurable range. Semi-quantitative bimolecular rate constants were obtained. mole-'sec.-l for piperidine) and were markedly decreased by steric hindrance in the amine.