Tetrahedron letters

Synthesis of medium ring lactams via cyclization reactions using polymer bound HOBT as catalyst

W Huang, AG Kalivretenos

Index: Huang; Wei, Huang; Kalivretenos; Kalivretenos, Aristotle G. Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9113 - 9116

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Citation Number: 41

Abstract

A typical experimental procedure for 2-azacyclotridecanone (7) is given below: A solution of N-tert-butoxycarbonyl-12-aminododecanoic acid (0.111 g, 0.410 mmol) in CH 2 Cl 2 (10 mL) was stirred with polymer-bound HOBT (0.80 g, 0.54 mmol/g, 1.0 equiv.) at 0 °C for 5 min. DCC