The Use of Biochemical and Biophysical Tools for Triage of High??Throughput Screening Hits–A Case Study with Escherichia coli Phosphopantetheine …

JR Miller, V Thanabal, MM Melnick…

Index: Chemical Biology and Drug Design, , vol. 75, # 5 p. 444 - 454

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Citation Number: 19

Abstract

... Chemical Biology & Drug Design, 75: 444–454. ... 19 F chemical shifts were referenced with respect to trifluoroethanol. ... these positive features, the compounds exhibit a dramatically pH-dependent binding profile and lack co-crystal structure(s) to guide medicinal chemistry efforts. ...