Bicyclic nucleoside inhibitors of Varicella–Zoster virus: The effect of branching in the p-alkylphenyl side chain

…, C McGuigan, G Andrei, R Snoeck, E De Clercq…

Index: Luoni, Giovanna; McGuigan, Christopher; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3791 - 3796

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Citation Number: 19

Abstract

Further to the discovery of bicyclic furanopyrimidine nucleoside analogues (BCNAs) as potent anti-VZV agents, a branched series of this family of compounds was synthesised. The aim was to study the impact of the geometry and steric hindrance in the side chain as well as lipophilic role of this moiety on biological activity. The results showed a detrimental effect of branching on antiviral activity, with a different magnitude depending on the position of ...