Kinetic resolution of homoaldols via catalytic asymmetric transacetalization

I Čorić, S Müller, B List

Index: Coric, Ilija; Vellalath, Sreekumar; List, Benjamin Journal of the American Chemical Society, 2010 , vol. 132, # 25 p. 8536 - 8537

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Citation Number: 139

Abstract

The highly enantioselective kinetic resolution of homoaldols via a transacetalization reaction has been achieved. A novel phosphoric acid, STRIP, based on a spirocyclic 1, 1′- spirobiindane backbone was designed and identified as a superior catalyst for this transformation. Remarkably, both secondary and tertiary homoaldols gave equally excellent results.