Tetrahedron Letters

A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195

L Stevenson, SL Pimlott, A Sutherland

Index: Stevenson, Louise; Pimlott, Sally L.; Sutherland, Andrew Tetrahedron Letters, 2007 , vol. 48, # 40 p. 7137 - 7139

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Citation Number: 17

Abstract

A new synthesis of the peripheral benzodiazepine receptor ligand, PK11195 has been developed in only six-steps using a Heck-type reaction and a Suzuki coupling to effect the key transformations. The flexibility of this new approach is demonstrated by the synthesis of an iodo-analogue of PK11195 prepared from the corresponding bromide using a copper catalysed aromatic Finkelstein reaction.