Nature Reviews Microbiology 2017-07-10

Structural biology: Cascade keeps its targets in the loop

Andrea Du Toit

Index: 10.1038/nrmicro.2017.80

Full Text: HTML

Abstract

This study presents cryo-electron microscopy structures of the type I-E Cascade and provides insights into PAM-dependent R-loop formation, Cas3 recruitment and substrate handover.

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