Inter-organ regulation of haem homeostasis

Jason N. Pitt, Matt Kaeberlein

Index: 10.1038/ncb3568

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Abstract

Haem is an iron-containing cofactor required for life. Many cellular processes rely on haem and failure to maintain iron homeostasis results in numerous pathological conditions. A study now identifies a Caenorhabditis elegans inter-organ signalling pathway in which secreted intestinal HRG-7 and neuronally secreted BMP signals coordinate animal haem homeostasis.