snoRNAs contribute to myeloid leukaemogenesis

Mona Khalaj, Christopher Y. Park

Index: 10.1038/ncb3566

Full Text: HTML

Abstract

The mechanism of action of oncogenes in acute myeloid leukaemia is poorly understood. A study now shows that the fusion oncoprotein AML1-ETO regulates leukaemogenesis by increasing the expression of small nucleolar RNAs through post-transcriptional mechanisms, resulting in increased ribosomal RNA methylation, protein translation, and promotion of leukaemic-cell self-renewal and growth.