Formation of N-acetyl-p-benzoquinone imine, the well-known toxic metabolite of acetaminophen, by the reaction of acetaminophen with nitrite under model stomach …
T Ohta, H Oribe, M Ide, S Takitani
Index: Ohta; Oribe; Ide; Takitani Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4634 - 4637
Full Text: HTML
Citation Number: 4
Abstract
The main reaction product of acetaminophen (4mM) with nitrite (1mM) under model stomach conditions was identified as p-benzoquinone. HPLC analysis of the reaction mixture with an electrochemical detector revealed the presence of N-acetyl-p-benzoquinone imine, the toxic
Related Articles:
Proceedings of the Chemical Society, Vol. 12, No. 169
[Friedlaender; Zeitlin Chemische Berichte, 1894 , vol. 27, p. 196]
[Zolfigol, Mohammad A.; Ghaemi, Ezat; Madrakian, Elaheh; Choghamarani, Arash G. Mendeleev Communications, 2006 , # 1 p. 41 - 42]
An efficient synthesis of a novel bifunctional chelating agent
[Erdogan, Belma; Akkaya, Engin U. Tetrahedron Letters, 1998 , vol. 39, # 49 p. 9107 - 9108]