An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

Jimmy Kuang-Hsien Hu, Wei Du, Samuel J. Shelton, Michael C. Oldham, C. Michael DiPersio, Ophir D. Klein

Index: 10.1016/j.stem.2017.03.023

Full Text: HTML

Abstract

Klein and colleagues show, using the mouse incisor as a model, that the transcriptional cofactors YAP and TAZ, components of the Hippo pathway, regulate stem cell-based tissue renewal by controlling the proliferation and differentiation of transit-amplifying cells in response to integrin/FAK signaling.