Ubiquinone and Related Compounds. XXVII. Synthesis of Urinary Metabolites of Phylloquinone and α-Tocopherol

M WATANABE, M KAWADA, M NISHIKAWA…

Index: Watanabe; Kawada; Nishikawa; Imada; Morimoto Chemical and Pharmaceutical Bulletin, 1974 , vol. 22, # 3 p. 566 - 575

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Abstract

The syntheses of the metabolites of phylloquinone, α-tocopherol and ubiquinones are described. 1. 2, 3, 5-Trimethyl-6-(3'-carboxybutyl)-1, 4-benzoquinone (VIIa), 2-methyl-3-(3'- carboxybutyl)-1, 4-naphthoquinone (VIIb) and 2, 3-dimethoxy-5-methyl-6-(3'-carboxybutyl)-1, 4-benzoquinone (VIIc) were synthesized by two routes. 2, 3, 5-Trimethylphenol (Ia) and 3- methyl-1-naphthol (Ib) were condensed with methylsuccinic anhydride (II), followed by ...