DEAD-Box RNA Binding Protein DDX5: Not a Black-Box during Reprogramming

Christian M. Nefzger, Jose M. Polo

Index: 10.1016/j.stem.2017.03.006

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Abstract

The role of RNA binding proteins (RBPs) during nuclear reprogramming is poorly characterized. In this issue of Cell Stem Cell, Li et al. (2017) show that DEAD-box RBP DDX5 acts as a reprogramming roadblock and give important mechanistic insights into the establishment of pluripotency by characterizing the intricate downstream events.