Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics

Athanasia D. Panopoulos, Erin N. Smith, Angelo D. Arias, Peter J. Shepard, Yuriko Hishida, Veronica Modesto, Kenneth E. Diffenderfer, Clay Conner, William Biggs, Efren Sandoval, Agnieszka D’Antonio-Chronowska, W. Travis Berggren, Juan Carlos Izpisua Belmonte, Kelly A. Frazer

Index: 10.1016/j.stem.2017.03.010

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Abstract

Working as part of the NHLBI NextGen consortium, Panopoulos et al. use iPSCs derived from monozygotic twins to examine factors regulating aberrant CpG methylation. Their findings suggest that aberrant methylation is likely due to a clone-associated biological mechanism involving Myc proteins and gene expression changes.