TLRgeting Evasion of Immune Pathways in Glioblastoma

Gaetano Finocchiaro

Index: 10.1016/j.stem.2017.03.018

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Abstract

Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activating downstream TLR signaling pathways can reduce tumor growth and disrupt CSC self-renewal.