The Relation of Estrogenic Activity to Structure in Some 4, 4'-Dihydroxydiphenylmethanes1

EE Reid, E Wilson

Index: Reid; Wilson Journal of the American Chemical Society, 1944 , vol. 66, p. 967

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Citation Number: 46

Abstract

2, 4, 6-Triisopropylbenzyl Cye1~ ide.~~-2, 4, 6-Triiiopropyl-benzyl chloride, prepared by the chloromethylation of 1, 3, 5-trii~ opropylbenzene,~ 6 was converted to the corresponding cyanide by treatment with cuprous cyanide. A mixture of 149 g. of the chloride, 57.8 g. of cuprous cyanide and 60 cc. of dry pyridine was heated at 21&220 for ninety minutes. When the mixture had cooled to 150" it was poured into a mixture of 500 g. of ice and 200 cc. of ...