Il Farmaco

Synthesis of some new biologically active thiadiazolotriazinones–Part III

…, BS Rao, R Gonsalves, BK Sarojini, K Shridhara

Index: Holla, B. Shivarama; Rao, B. Sooryanarayana; Gonsalves, Richard; Sarojini; Shridhara Farmaco, 2002 , vol. 57, # 8 p. 693 - 696

Full Text: HTML

Citation Number: 23

Abstract

4-Amino-6-arylmethyl/tert-butyl-3-mercapto-1, 2, 4-triazin-5 (4H)-ones (1) were condensed with arylfuroic acids (2) to yield 7-(5-aryl-2-furyl)-3-arylmethyl/tert-butyl-4H-1, 3, 4-thiadiazolo [2, 3-c]-1, 2, 4-triazin-4-ones (3). The newly synthesized compounds exhibited antibacterial activity comparable to that of nitrofurazone. In addition, two compounds displayed in vitro antitumor activity with moderate growth inhibition against a panel of 60 tumor cell lines.