Selective reductive carbonyl couplings with titanium

L Castedo, JM Saa, R Suau, G Tojo

Index: Castedo, Luis; Saa, Jose M.; Suau, Rafael; Tojo, Gabriel Journal of Organic Chemistry, 1981 , vol. 46, # 21 p. 4292 - 4294

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Citation Number: 18

Abstract

Considerable interest recently has been shown in the reductive coupling of ketones and aldehydes to olefins, using low-valent titanium reagents,'accessible from TiC13 or TiC14 by reduction with Zn, 394 Mg, 6 Zn-Cu couple: K, Li, &J or LiAlH4. 8 Intramolecular dicarbonyl coupling to cycloalkenes is also possible in high yield, including medium sized rings. & This formal reverse of a double bond ozonolysis appears to have great synthetic potential. ...