Synlett

N, N′-(Phenylmethylene) diacetamide analogues as economical and efficient ligands in copper-catalyzed arylation of aromatic nitrogen-containing heterocycles

JP Wan, YF Chai, JM Wu, YJ Pan

Index: Wan, Jie-Ping; Chai, Yun-Feng; Wu, Jian-Mei; Pan, Yuan-Jiang Synlett, 2008 , # 19 p. 3068 - 3072

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Citation Number: 9

Abstract

Abstract N, N′-(Phenylmethylene) diacetamide analogues which were simply prepared from the condensation reaction of an aldehyde with an amide or urea were found to be efficient ligands in copper-catalyzed coupling reaction of aryl halides with various azole nucleophiles. The newly developed ligand showed broad application scope in this conversion. Compounds including imidazoles, benzoimidazoles, pyrrole, indole, and ...