Synthetic communications

Microwave-promoted N-alkylation of acridones without solvent

C Wang, T Hang, H Zhang

Index: Wang, Cunde; Hang, Tianlong; Zhang, Hui Synthetic Communications, 2003 , vol. 33, # 3 p. 451 - 456

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Citation Number: 12

Abstract

View all references via microwave-induced reactions without solvent. We now describe here a remarkably rapid N-alkylation of acridone in dry media under microwave irradiation (Sch. 1). The reactions were carried out by simple mixing of acridone, alkyl halide, a catalytic amount of tetrabutylammonium bromide (TBAB) and NaOH/K 2 CO 3 adsorbed in Al 2 O 3 , and then by irradiating in an open vessel in a domestic microwave oven for 2–4 min.