Discovery of an androgen receptor modulator pharmacophore based on 2-quinolinones
…, M Wu, TK Jones, KB Marschke, A Negro-Vilar…
Index: van Oeveren, Arjan; Pio, Barbara A.; Tegley, Christopher M.; Higuchi, Robert I.; Wu, Min; Jones, Todd K.; Marschke, Keith B.; Negro-Vilar, Andres; Zhi, Lin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1523 - 1526
Full Text: HTML
Citation Number: 28
Abstract
A series of alkylamino-2-quinolinone compounds (3) was discovered as androgen receptor modulators based on an early linear tricyclic quinoline pharmacophore (1). The series demonstrated selective high binding affinity to androgen receptor and potent receptor modulating activities in the cotransfection assays.
Related Articles:
The Remarkable Effect of a Simple Ion: Iodide??Promoted Transfer Hydrogenation of Heteroaromatics
[Wu, Jianjun; Wang, Chao; Tang, Weijun; Pettman, Alan; Xiao, Jianliang Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9525 - 9529]
[Ueda, Masafumi; Kawai, Sayuri; Hayashi, Masataka; Naito, Takeaki; Miyata, Okiko Journal of Organic Chemistry, 2010 , vol. 75, # 3 p. 914 - 921]
Utilization of alkoxy ketones in the synthesis of quinolines by the Pfitzinger reaction
[Cross; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 2730,2732]
Utilization of alkoxy ketones in the synthesis of quinolines by the Pfitzinger reaction
[Cross; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 2730,2732]
Utilization of alkoxy ketones in the synthesis of quinolines by the Pfitzinger reaction
[Cross; Henze Journal of the American Chemical Society, 1939 , vol. 61, p. 2730,2732]