Substituted aryl malonamates as new serine β-lactamase substrates: Structure–activity studies

…, D Cabaret, JF Lohier, M Wakselman, RF Pratt

Index: Adediran; Cabaret; Lohier; Wakselman; Pratt Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 282 - 291

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Citation Number: 8

Abstract

A series of substituted aryl malonamates have been prepared. These compounds are analogues of aryl phenaceturates where the amido side chain has been replaced by a retro- amide. Like the phenaceturates, these compounds are substrates of typical class A and class C β-lactamases, particularly of the latter, and of soluble DD-peptidases. The effect of substituents α to the ester carbonyl group on turnover by these enzymes is similar to that ...